A new PET probe, 18F-tetrafluoroborate, for the sodium/iodide symporter: possible impacts on nuclear medicine
نویسندگان
چکیده
منابع مشابه
[18F]tetrafluoroborate as a PET tracer for the sodium/iodide symporter: the importance of specific activity
BACKGROUND [(18)F]BF4 (-), the first (18)F-labelled PET imaging agent for the sodium/iodide symporter (NIS), was produced by isotopic exchange yielding a product with limited specific activity (SA, ca. 1 GBq/μmol) posing a risk of sub-optimal target-to-background ratios (TBR) in PET images due to saturation of NIS in vivo. We sought to quantify this risk and to develop a method of production of...
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BACKGROUND Recently, 18F-tetrafluoroborate (TFB) was used as a substrate for the human sodium/iodide symporter (hNIS) reporter gene. This study evaluated the feasibility of performing molecular-genetic imaging by using the new radiotracer (18F-TFB) for the hNIS gene, to track dendritic cell (DC) migration in live mice. A murine dendritic cell line (DC2.4) co-expressing the hNIS and effluc genes...
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ژورنال
عنوان ژورنال: European Journal of Nuclear Medicine and Molecular Imaging
سال: 2010
ISSN: 1619-7070,1619-7089
DOI: 10.1007/s00259-010-1601-3